Additionally, when stimulated by cytokines such as interferon-gamma (IFN-γ) and IL-17 from CD4+ Th cells, the choroid plexus epithelium expresses unique trafficking molecules and releases chemoattractant ligands such as CCL20, which promote the transmigration of preactivated B cells and T cells into the CSF in experimental autoimmune encephalomyelitis (EAE) mouse models for MS (24, 25). This evidence concerns the gene CD4 and myeloid sarcoma.