The roles of integrin activating molecules including talins and kindlins, however, are unclear in SSc.<h4>Objectives</h4>We aimed to explore the function of integrin activating molecules in SSc.<h4>Methods</h4>Transcriptome analysis of skin datasets of SSc patients was performed to explore the function of integrin-activating molecules including talin1, talin2, kindlin1, kindlin2 and kindlin3 in SSc. Here, TLN1 is linked to systemic sclerosis.