We further assessed the permeability of intestinal mucosal barrier and found that compared with sham rats, HF model rats presented increased mean plasma levels of LBP (114.0±47.0 μmoL vs 170.6±48.5 μmoL,P=0.04) and zonulin (1040.5±91.3 mg/L vs 1176.0±53.8 mg/L,P=0.001). The gene discussed is LBP; the disease is hydrops fetalis.