In particular, the results revealed a remarkable increase in ANP in the HF group compared with the sham group (ANP, 11.0±7.4 ng/mL vs 33.2±11.4 ng/mL,P<0.001), and this increase was reversed by NaB administration (ANP, 33.2±11.4 ng/mL vs 24.5±5.4 ng/mL,P=0.031). Here, NPPA is linked to hydrops fetalis.