The protein levels of occludin, ZO-1, and GPR109A were significantly decreased in the intestinal tissue of HF model rats, and these changes were reversed by treatment with NaB (GPR109A,P<0.001; occludin,P=0.044; ZO-1,P<0.001) (Figure 7B‒D). The gene discussed is TJP1; the disease is hydrops fetalis.