Furthermore, the knockdown of HOXA5 remarkably attenuated enhancer activity of rs3094296-T allele in a dose-dependent manner in HCT116 and SW480 cell lines, but had no effect on HIEC-6 cells (Fig. 5i; Additional file 2: Fig. S14), indicating preferential binding of HOXA5 to rs3094296-T allele in the tumor states. The gene discussed is HOXA5; the disease is neoplasm.