It was observed that 17 TFs were strongly enriched in the tumor-specific eRNAQTLs, all of which were also significantly upregulated in CRC (Fig. 4d), including canonical cancer-associated TFs such as bromodomain containing 9 (BRD9), cAMP responsive element binding protein 1 (CREB1) and CCAAT enhancer binding protein beta (CEBPB). This evidence concerns the gene CREB1 and neoplasm.