Differential gene expression analysis (DEG) demonstrates that mRNAs of several genes in the top-ranked Purple protein cluster (Fig. 8B) are upregulated in PD blood including TYROBP (log2FoldChange = 0.22, Benjamini-Hochberg corrected p = 5.07 × 10− 6) and CD14 (log2FoldChange = 0.23, Benjamini-Hochberg corrected p = 6.56 × 10− 5). This evidence concerns the gene TYROBP and Parkinson disease.