FUS and amyotrophic lateral sclerosis: Endogenous FUS aggregation was observed at 1 month post-injection around the site of injection in the hippocampus region, a region associated with pathology in both ALS and FTLD patients [2, 59] and in the cortical region, where basophilic and FUS positive inclusions are found in neurons and glia cells of ALS cases, and are numerous in the middle and deep layers of the neocortex in FTLD [45, 60].