The FUS homologue TATA-binding protein-associated factor 15 (TAF15) (also known as TATA-binding protein-associated factor 2N), but not the RNA binding protein TDP-43, was also present in a detergent insoluble fraction, consistent with increased FUS and TAF15 insolubility reported in ALS/FTLD-FUS patients [56, 58] and extraction and imaging of filaments of TAF15 from such patient samples [58]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.