AST-specific PTVs (HR = 2.20, 95% CI 1.54–3.15) and GGT-specific PTVs (HR = 1.82, 95% CI 1.24–2.65) increased the risk of NAFLD, while ALT-specific (HR = 4.14, 95% CI 1.03–16.63) increased the risks of viral hepatitis. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.