PTVs in pathways the valine/leucine/isoleucine degradation (HR = 11.40, 95% CI 1.60–81.15), pyruvate metabolism (HR = 14.18, 95% CI 4.55–44.13), PPAR signaling pathway (HR = 7.91, 95% CI 1.97–31.74), and carbon metabolism (HR = 7.75, 95% CI 1.09–55.15) significantly increased the risk of liver disease mortality. This evidence concerns the gene PPARA and liver disorder.