Therefore, in SLE and COVID-19, both hub genes and core TFs are enriched within monocytes/macrophages.<h4>Conclusions</h4>The interaction between SLE and COVID-19 promotes the activation of the IFN-I/II-triggered JAK-STAT signaling pathway in monocytes/macrophages. This evidence concerns the gene SOAT1 and systemic lupus erythematosus.