Propensity score matching (PSM) was used to verify the results.<h4>Results</h4>In this study, 2042 patients with sepsis and changes in HGB levels at day 4 after admission compared to day 1 were enrolled and divided into two groups: group 1 (n = 1147) for those with reduction of HGB < 7% and group 2 (n = 895) for those with dropping ≥ 7%. This evidence concerns the gene CYGB and Sepsis.