The overlapping genes included known AD markers which changed in more than 7 different studies26, including the lipid metabolism genes Abca1 and Apoe27; complement immune system members C4b, Ctsd, C1qb and C1qa28, and the astrocytic markers Gfap and Aqp429 (Supplementary Data 1). Here, ABCA1 is linked to Alzheimer disease.