CASP14 and skin disorder: Overall, molecular alterations observed in the space flown mice and astronaut skin data show similarities with molecular effects associated with drugs like tretinoin and tamoxifen123, such as FLG and CASP14 downregulation, while symptoms reported in astronauts including dry skin and dermatitis also resemble side effects associated with drugs like tretinoin and tamoxifen106 (Fig. 9).