Lastly, genes such as COL6A2 and FKBP14, a collagen/ECM related gene associated with diseases such as kyphoscoliotic Ehlers-Danlos syndrome that is characterized by joint hypermobility, hyperelastic skin, hearing impairment, muscle hypotonia and occasional vascular fragility like aortic rupture73, were downregulated in-flight and their average expression persisted post-flight (Supplementary Fig. 3b). Here, COL6A2 is linked to Ehlers-Danlos syndrome.