CXCL1 and lung adenocarcinoma: Tanaka et al. reported that SRGN can increase the migratory and invasive properties of tumour cells and fibroblasts in lung adenocarcinoma by regulating the expression of PD-L1 and pro-inflammatory cytokines such as IL-6, IL-8, and C-X-C motif chemokine 1 [39].