CTSA and myocardial infarction: By analyzing heart samples taken from our well-established murine MI models (McCarroll et al. 2018; He et al. 2022; Martin et al. 2022), we have detected 10 cathepsin members (cathepsin A, B, C, D, F, G, H, L, S, Z) with DIA-based quantitative proteomics and found the expression of these cathepsins all trended toward upregulation in the BZ following MI and inhibition of RUNX1 tended to normalize their expression levels.