By analyzing heart samples taken from our well-established murine MI models (McCarroll et al. 2018; He et al. 2022; Martin et al. 2022), we have detected 10 cathepsin members (cathepsin A, B, C, D, F, G, H, L, S, Z) with DIA-based quantitative proteomics and found the expression of these cathepsins all trended toward upregulation in the BZ following MI and inhibition of RUNX1 tended to normalize their expression levels. This evidence concerns the gene CTSS and myocardial infarction.