CTSS and myocardial infarction: Multiple lines of evidence suggest that the beneficial effects on infarct size obtained by inhibiting RUNX1 are associated with repressed cathepsin levels: (1) RUNX1 expression is increased in the BZ and IZ regions of the heart at an early-stage following MI and mediates impaired cardiac function (McCarroll et al. 2018; Martin et al. 2023; Kubin et al. 2011; Gattenlohner et al. 2003).