CHIP carrier status may therefore exacerbate health risks associated with space radiation exposure.<h4>Methods</h4>In the present study, published CHIP hazard ratios were used to modify background hazard rates for coronary heart disease, stroke, and hematologic cancers in the National Aeronautics and Space Administration space radiation risk assessment model. The gene discussed is STUB1; the disease is hematopoietic and lymphoid cell neoplasm.