Dravet syndrome can be modeled in mice by heterozygous deletion of Scn1a. Several mouse models with varying deletions have been generated and share similar phenotypes, including spontaneous and hyperthermia-induced seizures (Miller et al. 2014; Ogiwara et al. 2007; Yu et al. 2006). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.