The aspect of LPS signalling that leads to increased internalization of SARS-CoV-2 PVs is unclear, but NFκB is an interesting target, as its levels are also increased by APOE4 genotype [65] as well as conditions such as diabetes and obesity that increase the risk of severe COVID-19 disease [66]. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.