S100A8 and infection: This included (i) survival analysis of Diversity Outbred mice carrying PWK/PhJ alleles at the H-2 locus in Dots8 on chromosome 17; (ii) quantification of S100A8 protein levels in lungs of M. tuberculosis infected PWK/PhJ and CAST/EiJ inbred founder strains; and (iii) infection of S100a8 C57BL/6 gene deficient mice.