Considering the suspected dual impact of obesity on Kiss1 neurons (3), with initial over activation followed by long-term suppression, our data suggest that this astrocyte regulatory circuit, parallel to the direct effects of kisspeptins on GnRH neurons, contributes to adaptive responses of the reproductive axis to obesogenic stressors, both during puberty and adulthood, mainly in females. The gene discussed is GNRH1; the disease is obesity disorder.