These phenotypic features are different from those of global Kiss1r-KO mice (27), which suffer from severe central hypogonadism, or mice with conditional inactivation of Kiss1r in GnRH neurons, which phenocopy global Kissr1-KO mice (4, 5), or in POMC neurons, which are devoid of a detectable phenotype (47) (Supplemental Table 1). Here, KISS1R is linked to hypogonadotropic hypogonadism.