LRPAP1 and glioblastoma: Exploiting this property for GBM therapy, Ruan and co-workersdesigned a miniaturized RAP protein using a Monte Carlo-based algorithm,resulting in the development of the RAP12 peptide (EAKIEKHNHYQK).RAP12 was used to modify paclitaxel (PTX) loaded-poly(ethylene glycol)-block-poly(lactic acid) (PEG–PLA) micelles, exhibitinga solid ability to cross the BBB and target GBM.