The Pep-1 (CGEMGWVRC) peptidewas also used as a binding ligand of IL-13Rα2 in targeting NPs,exhibiting high targeting efficiency and specificity for GBM cells.67−69 Jiang et al. designed PEGylated polyamidoaminedendrimers modified with Pep-1, where this peptide served as an anchorto enhance the delivery of NPs across BTB and target them specificallyto glioma cells. The gene discussed is IL13RA2; the disease is central nervous system cancer.