Yang and co-workers developed cationic liposomes coloaded withDTX and vascular endothelial growth factor (VEGF) small interferingRNA (siRNA) conjugated with ANG2 and tLyp-1 to improve BBB penetrationand GBM targeting, demonstrating a superior efficacy against GBM.121,122 Another peptide, Ft peptide, was designed by combining tLyp-1 andFHK peptide (FHKHKSPALSPV) to target NRP-1 and tenascin C, respectively- both receptors overexpressed in GBM. The gene discussed is VEGFA; the disease is glioblastoma.