TFRC and neoplasm: In vivo studies also showedthe smallest tumor size and significantly longer survival in the targetedgroup.51 Also, functionalization of PTX-loadedPLGA NPs with CRT (CRTIGPSVC) peptide, an allosteric TfR binding peptide,has revealed enhanced accumulation in GBM cells and prolonged mousesurvival compared to nonfunctionalized NPs.52 Additionally, PEG–PLA micelles modified with TfR-T12 (THRPPMWSPVWP)peptide were designed, with both in vitro and in vivo results revealing the efficacy of this peptide incrossing BBB and target tumor cells.53