Chlorotoxin(CTX), a scorpion venom-derived peptide consistingof 36 amino acids, exhibited a strong affinity for both matrix metalloproteinase2 (MMP-2) and chloride channel-3 (ClC-3), which are significantlyoverexpressed in GBM cells but absent in healthy brain tissue.95,96 NPs conjugated with CTX showed promise as a strategy for targetedGBM delivery. Here, CLCN3 is linked to glioblastoma.