In the miceorthotopic model, c(RGDyK) modified RBCm coated NPs significantlyprolonged the median survival time (62 days) compared to nonfunctionalizedbiomimetic NPs (34.5 days) and the control group (32 days).196 Beyond erythrocyte membrane strategies, Wangand co-workers developed a nanomedicine cloaked with GBM cancer cellsto take advantage of the homotypic binding mechanism of these membranes.These NPs were further decorated with an ApoE peptide for the codeliveryof TMZ and lomeguatrib - a MGMT inhibitor. This evidence concerns the gene APOE and glioblastoma.