TFRC and central nervous system cancer: Indeed, resultsfrom an orthotopic glioma-bearing model showed that nanocarriers functionalizedwith TfR-T12 peptide had the most extended median lifespan (42 days)compared to nonfunctionalized nanocarriers (28 days) and the salinegroup (24 days).199 A ferritin nanocagecoloaded with epirubicin (EPI) and CPT, possessing inherent TfR targetingcapabilities, was further enhanced by attaching RGD peptides to itsouter surface.