Nanocapsulesfunctionalized with NFL decreased the proliferation and self-renewalcapacity of GSCs.113 Moreover, in vitro studies revealed that liposomes modified with NFLpeptide increased their ability to penetrate GBM cells after passingthrough the BTB, demonstrating the ability of NFL to cross brain ECs.114 Other strategies involved a responsive peptideto the tumor microenvironment. The gene discussed is NEFL; the disease is glioblastoma.