It increases the sensitivity of tumor cells to radiation,enabling targeted treatment and reducing side effects on healthy tissues.4,177 RT has been proven to effectively increase the accumulation of NPsin tumors and improve their intratumoral distribution through shorttreatment sessions.178 Tamborini and colleaguesinvestigated the potential synergy between RT and functionalized NPs.For this purpose, they used PLGA NPs modified with the CTX peptide,taking advantage of their binding properties to MMP-2 and ClC-3. Here, MMP2 is linked to neoplasm.