This dual-functionalized approach was ableto cross the BBB/BTB and target GBM cells, with in vivo studies showing a significant improvement in mean survival time.132 Zhang et al. developed TMZand vincristine-coloaded nanostructured lipid carriers decorated withRGD peptide and lactoferrin (Lf), a member of the Tf family whosereceptor showed to be overexpressed in GBM cells. This evidence concerns the gene LTF and glioblastoma.