In vivo research verified that this dual modification led to enhanced NPaccumulation and deeper penetration into GBM tissue, with an observedincrease in median survival time.136 Ina different approach, Lv et al. developed dual-functionalizedPTX-loaded PEG–PLGA NPs with CGKRK peptide and Pep-1 to targetheparan sulfate receptor in the BTB and IL-13Rα2 at GBM cells,respectively. This evidence concerns the gene IL13RA2 and glioblastoma.