MAP1LC3B and metastatic neoplasm: For example, recent studies have shown punctate staining or increased expression of microtubule-associated protein 1 light chain 3 beta (LC3B) in various metastatic tumors, suggesting that autophagy is upregulated during metastasis (Peng et al. 2013; Lazova et al. 2012; Zhao et al. 2013; Han et al. 2011).