HSPA8 and breast angiosarcoma: We hypothesized that RRV’s “SRL” interaction with Hsc70 affects the viral trafficking pathway as we have previously demonstrated the amino acid sequence “SRL” expressed on RRV’s VP4 protein governs attachment by binding to Hsc70 expressed on the cell surface and altering this sequence inhibits the strain’s ability to induce murine BA (10, 24).