Altering one amino acid in RRV’s “SRL” sequence to “SGL” (RRVVP4-R446G) renders it incapable of binding to Hsc70 and therefore unable to induce obstruction in the murine model of BA, conversely, Ro1845 is unable to bind to Hsc70 but when its “SGL” sequence is altered to “SRL” (Ro1845VP4-G446R), it can bind to Hsc70 and induce this obstruction (23, 24). The gene discussed is HSPA8; the disease is breast angiosarcoma.