Viral titers performed on bile ducts harvested from WT-BALB/c and TLR3 KO mice 7 and 10 days post-RRV infection demonstrated equal infection at day 7 while day 10 post-RRV-infected TLR3 KO mice have significantly higher viral titers than WT-BALB/c mice, indicating an ongoing, unregulated viremia (Fig. 8E). Here, TLR3 is linked to infection.