Recently, in murine infection studies, we reported mechanistic insights on the role of 2-AA in decreasing bioenergetics and ATP production in macrophages involving the impaired interaction between estrogen-related nuclear receptor alpha (ERRα) and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) that impacts the pyruvate transport into mitochondria (65). The gene discussed is ESRRA; the disease is infection.