CD4 and Sepsis: <h4>Objective</h4>This study aimed to link intracellular adenosine triphosphate content in CD4<sup>+</sup> T lymphocytes (CD4<sup>+</sup> iATP) with sepsis patient mortality, seeking a new predictive biomarker for outcomes and enhanced management.<h4>Methods</h4>61 sepsis patients admitted to the Intensive Care Unit between October 2021 and November 2022 were enrolled.