These results echoed findings by other groups that IFNAR deficiency in non-lupus B6 mice induced photosensitivity (Sontheimer et al., 2017) and reduced skin wound healing (Gregorio et al., 2010; Wolf et al., 2022), and we considered the possibility that the 500 μg anti-IFNAR dose perhaps mimicked complete IFNAR deficiency and disrupted normal skin functions, thus obscuring the effects of LC ADAM17 activity restoration. This evidence concerns the gene IFNAR1 and systemic lupus erythematosus.