ADAM17 and systemic lupus erythematosus: These results echoed findings by other groups that IFNAR deficiency in non-lupus B6 mice induced photosensitivity (Sontheimer et al., 2017) and reduced skin wound healing (Gregorio et al., 2010; Wolf et al., 2022), and we considered the possibility that the 500 μg anti-IFNAR dose perhaps mimicked complete IFNAR deficiency and disrupted normal skin functions, thus obscuring the effects of LC ADAM17 activity restoration.