By GSVA using lupus-relevant murine gene sets (Supplementary file 9), MRL/lpr mice showed increased enrichment of a number of inflammatory cell and cytokine gene sets including T cells, myeloid cells, neutrophils, pDCs, IFN, IL1, IL21, and TNF (Figure 3A). The gene discussed is IL21; the disease is systemic lupus erythematosus.