LCs from the B6.Sle1yaa model showed a 63% reduction in UVR-induced TNFR1 loss when compared to control B6 mice without a corresponding change in cell surface ADAM17 protein levels (Figure 6E–F), suggesting reduced LC ADAM17 sheddase function in this SLE model. This evidence concerns the gene ADAM17 and systemic lupus erythematosus.