BRAF and cardiofaciocutaneous syndrome 1: Neurological development was assessed using electroencephalography (EEG), magnetic resonance imaging (MRI) and Gesell developmental evaluation.<h4>Results</h4>All four CFCS patients exhibited <i>de novo BRAF</i> gene mutations, manifesting with cardiac malformations, distinctive facial features, skin and hair changes, and neurological abnormalities.