LIAS and neoplasm: Furthermore, we observed a significant downregulation of LIAS, a key enzyme in mitochondrial lipoid acid synthesis,[26] in tumor cells from combination therapy groups (Figure 4E), providing further evidence supporting the connection between copper‐mediated cell death and LIAS instability, as previously reported.[9] Collectively, these results provide compelling preclinical evidence that the combination of copper ionophores with ENZ represents a promising therapeutic strategy for CRPC.