we would highlight 4 overlapped loci across 10 pairs of all the traits, including GCKR, MUC1, HSPA1A and KRT18P1. Furthermore, we found 3 novel genes identified by both MTAG and TWAS, including PTPRJ, IBSP and SUFU. TWAS analysis showed that the shared genes between kidney function biomarkers and mental disorders might express via the nervous, cardiovascular, exo-/endocrine system and digestive systems. This evidence concerns the gene PTPRJ and mental disorder.