Five index SNPs were associated with higher risk of CKD with a p-value < 9E-07 in 373,164 participants of the Overall Cohort of the UKB (NAT8-rs13538A, CPS1-rs1047891A, SLC22A2-rs3127573G, GATM-rs58764877C, WDR72-rs72747347C) (Supplementary Table 19). This evidence concerns the gene SLC22A2 and chronic kidney disease.