In 490 T2DM patients and 485 healthy controls, NOS3-rs3918188 was associated to susceptibility to T2DM; the rs1800783 polymorphism (R2 = 0.1404 with rs3918226) predicted DKD, and family history of diabetes was closely associated with rs11771443 (R2 < 0.1 with rs3918226) polymorphism in DKD [67]. Here, NOS3 is linked to type 2 diabetes mellitus.