Interestingly, our analysis, not only confirms the association of rs2853499 and rs2853503 variants in MT-ND5 with serum variables, but also newly identifies the MT-ND5-rs41535848G variant, along with the mitochondrial haplogroup X, associated with higher risk of ESKD in the Overall/Non-Diabetic Cohorts, emphasising the role of this gene in kidney disease. Here, MT-ND5 is linked to kidney disorder.