The AGXT2-rs71615838G variant, associated with lower risk of DKD in the UK-ROI collection, showed a different effect in the Diabetic Cohort of the UKB (increased ESKD risk and SCysC levels, decreased eGFRCysC and eGFRCreaCysC), but this was not significant after multiple comparisons correction (Table 2). Here, AGXT2 is linked to diabetic kidney disease.