The top SNP associated with the primary DKD phenotype identified in a combined GWAS meta-analysis of discovery and second stages in DKD individuals (6, 691) was rs7588550 (R2 < 0.1 with rs10168303), an intronic SNP in the ERBB4 gene, which demonstrated consistent protective effects in the replication samples (OR = 0.66; CI95%: 0.56–0.77; P = 2.1E-07) [76]. The gene discussed is ERBB4; the disease is diabetic kidney disease.