In addition to the GATM variant discussed above (rs2433610), another variant in SPATA5L1, close to GATM, was associated with eGFRCrea in 2,388 CKD cases included among the participants of four different population-based cohorts of European-ancestry (Beta: -0.013; SE: 0.002; P = 6.2E-14) [54]. Here, AFG2B is linked to chronic kidney disease.