The fact that multiple associations within WDR72 have been shown across different ethnicities suggest that this gene may have relevance for kidney function across multiple ancestries. A recent transethnic GWAS meta-analysis, including participants from the UK and Japan Biobanks, to understand the common genetic factors contributing to nephrolithiasis, identified a potential role of the intronic rs578595 variant in WDR72 in calcium-sensing receptor (CaSR) signalling [130]. This evidence concerns the gene CASR and nephrolithiasis.