NOS3 and autosomal dominant polycystic kidney disease: A recent meta-analysis of 13 studies found that two NOS3 gene polymorphisms (rs1799983, R2 = 0.189 with rs3918226 and the intron 4 VNTR a/b polymorphism) significantly increased ESKD risk in autosomal dominant polycystic kidney disease (ADPKD) patients [62].