CPS1 and chronic kidney disease: Genes like SLC22A2 [57, 108, 109, 127, 128], CPS1 [109], WDR72 and WDR37 [57, 109, 127–129] have shown specific association with eGFRCrea, therefore have been proposed to be involved in creatinine secretion, rather than kidney function, and consequently may not be representative of CKD.