Another SNP, located in the 3′ untranslated region of the CPS1 gene, rs715 (in LD with rs1047891: R2 = 0.907), previously associated with CKD [109], also showed an association with glycine levels in 1,004 nondiabetic individuals from the RISC study (P = 3.3E-50) [118]. Here, CPS1 is linked to chronic kidney disease.