In support of this, the circulating and urinary levels of 14 N-acetylated amino acids were associated with NAT8-rs13538 variant in 962 participants of the African American Study of Kidney Disease and Hypertension, 1050 from the Atherosclerosis Risk in Communities study and 680 from the electronic health record-linked biorepository BioMe [115, 116]. Here, NAT8 is linked to hypertensive disorder.