ADCYAP1 and migraine disorder: In this study, we investigate the relationship between female sex hormones and Pituitary Adenylate Cyclase-Activating Polypeptide-38 (PACAP-38) concentrations in plasma of women with migraine and healthy controls, aiming to elucidate potential hormonal influences on PACAP dynamics and their relevance to migraine pathophysiology.<h4>Methods</h4>This analysis is part of a cross-sectional, matched-cohort study.