ALK and neuroblastoma: These studies have been complemented by recent proximity labeling BioID experiments to define an ALK interactome in NB cell lines [41], that confirmed many previously identified ALK signal transduction components, such as the IRS2, SHC, GAB1, FRS2, CRK and CRKL adapter proteins, the pseudokinase PEAK1 and the protein tyrosine phosphatase SHP2.