Treatment of three additional NB cell lines, CLB-BAR (ALK-Δexon4-11), CLB-GE (ALK-F1174V) and CLB-GAR (ALK-R1275Q), confirmed that ALK signaling is required for SLC3A2 protein stabilization in a range of NB cell lines (Fig. 1D, Sup. The gene discussed is CLYBL; the disease is neuroblastoma.