GSEA Gene Ontology analysis identified a strong enrichment of biological pathways related to amino acid transport in NB tumors from both ALK gain-of-function mice (Alk-F1178S;Th-MYCN, NES = 1.9, P = 5.8E-7) and ALKAL2 overexpressing mice (Rosa26_Alkal2;Th-MYCN, NES = 1.6, P = 3.5E-4) compared to Th-MYCN mice (Fig. 6A, Sup. This evidence concerns the gene ALK and neuroblastoma.