Furthermore, targeting this complex, which is downstream of IKK action, also allows blocking of both the cancer cell-intrinsic and -extrinsic TME reshaping feed-forward loops between cancer cells and GAMs (the extrinsic feed-forward loop is highlighted in a red dashed box in Supplementary Fig. 4) while leaving other pathways like β-catenin and p53 intact. The gene discussed is TP53; the disease is cancer.