We find that LOC expression is significantly dampened in IDH-R132H gliomas (Fig. 2a,g), and administration of IDH-mutant-specific inhibitor (AGI-5198) restores LOC expression (Fig. 2h), suggesting that treatment with IDH-R132H inhibitor may reactivate the LOC–DHX15 axis in IDH-mutant gliomas. This evidence concerns the gene DHX15 and central nervous system cancer.