IDH1 and glioblastoma: However, the highest rates of tumour regression and the most favourable survival were observed when LOC/Gm16685 were removed from both cancer cells and TME (green trace; Fig. 6b,c), thereby highlighting the cell-intrinsic and -extrinsic roles of Gm16685/LOC in shaping the IDH-wild-type glioblastoma TME.