Among the four significant variants, three had been previously implicated in PD, including c.1093G > A/p.E365K in GBA; c.6055G > A/p.G2019S and c.4321C > T/p.R1441C in LRRK2 (test statistics for all known PD variants are provided in Supplementary Data 2). This evidence concerns the gene GBA1 and Parkinson disease.