TB was associated with elevated levels of macrophage markers (MARCO, SOCS3, FCGR1A, MPO, C1QB), neutrophil markers (ELANE, FCGR3A, S100A8, S100A9, ERG), interferon genes (IFI27L1, IFIT2, IFIT3, IFITM3, IRF1), and antimicrobial genes (AZU1, CTSG, DEFA4, STAT1, GBP1, GBP2, GBP4, GBP5, GBP6) compared to the TB negative group. This evidence concerns the gene IRF1 and tuberculosis.