TB was associated with elevated levels of macrophage markers (MARCO, SOCS3, FCGR1A, MPO, C1QB), neutrophil markers (ELANE, FCGR3A, S100A8, S100A9, ERG), interferon genes (IFI27L1, IFIT2, IFIT3, IFITM3, IRF1), and antimicrobial genes (AZU1, CTSG, DEFA4, STAT1, GBP1, GBP2, GBP4, GBP5, GBP6) compared to the TB negative group. Here, GBP6 is linked to tuberculosis.