MAPT and Atrophy: In order to better understand the causal links between Tau hyperphosphorylation and sleep disruption and to ask whether there may be sex-specific vulnerabilities to sleep disruption, we first investigated the onset and progression of sleep disruption in PS19 mice by measuring sleep behavior at 3 months (prepathology), 6 months (early pathology), 9 months (late pathology, early atrophy), and 11 months (late pathology, late atrophy; Yoshiyama et al., 2007; Dejanovic et al., 2018).