PLA2G15 and age-related macular degeneration: Based on the cellular location and enzymatic properties of AHBD6 and LPLA2, and the AMD-responsive phenotype of AHBD6 or LPLA2 deficient mice, it is possible that both enzymes have a role in the catabolism of BMP, in which ABDH6 and LPLA2 act at the cytosolic site and the luminal sides of the lysosome, respectively.