In addition, when 7-days AMD-treated cells were cultured for 24 h in AMD-free fresh medium in the presence of active recombinant LPLA2 or DFP-inactivated recombinant LPLA2, BMP levels in AMD-treated RAW-267.4 cells were significantly reduced by treatment with the active enzyme but not with the inactive enzyme (Fig. 7A, C, E). The gene discussed is PLA2G15; the disease is age-related macular degeneration.