The relationships of Uosm with effects on TKV and eGFR are supported by research on V2R physiology and the role of V2R activation in ADPKD.10 Antagonism of V2R by tolvaptan both counteracts the antidiuretic effect of vasopressin and inhibits the effects of vasopressin on cyst development and expansion. This evidence concerns the gene AVPR2 and cyst.