In the discovery cohort, the performance of temporal meta-ROI and tau PET visual reads to predict all-cause dementia were better in younger individuals than in older individuals (eFigure 4 in Supplement 1) and all neuroimaging markers performed better in APOEε4 noncarriers vs APOEε4 carriers (eFigure 5 in Supplement 1) when predicting AD dementia. This evidence concerns the gene MAPT and dementia.