The increased performance of temporal meta-ROI tau to predict all-cause dementia over the base model (AUC, 0.85; 95% CI, 0.75-0.95 vs AUC, 0.73; 95% CI, 0.59-0.88; P = .04) was replicated in the validation cohort, while the model including tau PET visual read also performed better than the base model in the validation cohort (AUC, 0.85; 95% CI, 0.75-0.94; P = .04). The gene discussed is MAPT; the disease is dementia.