ALKBH5 activates Period1 (PER1) gene through m6A demethylation and in an m6A-YTHDF2-dependent manner, reactivating the Ataxia telangiectasia mutated/checkpoint kinase 2/tumor protein 53/cell division cycle 25C signaling pathway and inhibiting the proliferation, migration, and invasiveness of pancreatic cancer cells [158]. Here, YTHDF2 is linked to familial pancreatic carcinoma.