Molecular investigations indicate that ALKBH5 collaborates with METTL14/IGF2BPs to suppress tumor cell glycolysis by negatively regulating the Jumonji domain-containing protein 8 (JMJD8)/pyruvate kinase M2 (PKM2) signaling axis, slowing down colorectal cancer progression [140]. The gene discussed is METTL14; the disease is colorectal cancer.