Hence, we investigated the responsiveness of the p53 and PTEN pathways to FOSL1 by evaluating the levels of p53 or PTEN proteins in glioma cell lines known for their functional status of p53 (wtp53), such as A172, U87MG, and for the functional PTEN status (wtPTEN) like PDX-L14 cells. The gene discussed is TP53; the disease is glioma.