Our data indicate that in glioma cell lines expressing wild type p53 (wtp53, such as A172 and U87MG cells) and/or PTEN (wtPTEN, such as PDX-L14), FOSL1 positively influenced NF-κB while diminishing the protein expressions of p53 and PTEN, thereby directly activating of NF-κB. The gene discussed is PTEN; the disease is glioma.