Subsequent qPCR validation confirmed a significant increase in mRNA levels of CD30 (Fig. 1E), PRKCQ (Fig. 1F), and ADAM8 (Fig. 1G) in glioma cell lines (A172, U87MG, and PDX-L14) overexpressing FOSL1, which are key regulators at the apex of the NF-κB signaling pathway. The gene discussed is ADAM8; the disease is central nervous system cancer.