Moreover, consistent with previous reports of the DAC enhancement of major histocompatibility complex class I (MHC-I) in other cancer types and in glioma (10, 38), DAC-upregulated pan-MHC-I genes (HLA-A/B/C) across all cell populations in our dataset (Fig. 3F; Supplementary Fig. S4C). The gene discussed is HLA-A; the disease is central nervous system cancer.