CHEK2 and breast carcinoma: To date, the literature is mostly comprised of case series (105 and 299 patients) and case reports of colon and breast cancer in individual patients, all of which have an average age around 65.11-18 Only a few case reports exist for young patients and only 5 case reports on patients less than 60 years old were identified.15,19 Additionally, only one case demonstrated a genetic mutation (CHEK2*1100delC) to explain both a hereditary breast and CRC phenotype.20