The V600E mutation in BRAF leads to excessive activation of the kinase, triggering uncontrolled cell division and contributing to cancer development (H. Davies et al. 2002; Li et al. 2006; D. Liu, Liu, Condouris, and Xing 2007; Sanchez-Torres, Viteri, Molina, and Rosell 2013; Ritterhouse and Barletta 2015). The gene discussed is BRAF; the disease is cancer.