Although the degree of glycolytic activity in proximal tubular cells is still disputed (28, 29), using kidney tissue scRNA-Seq data from the KPMP Kidney Tissue Atlas (30), we observed higher expression of several glycolytic genes, including PKM, LDHA, and HKDC1 in the proximal tubule from participants with diabetes compared with healthy controls. Here, HKDC1 is linked to diabetes mellitus.