Several genes involved in early- and late-stage glycolysis were significantly upregulated in the proximal tubule of participants with DKD, including pyruvate kinase (PKM), lactate dehydrogenase A (LDHA), and hexokinase domain containing 1 (HKDC1), compared with healthy controls (Figure 4A and Table 3). This evidence concerns the gene LDHA and diabetic kidney disease.