Here, we investigated the utility of FcαRI targeting to induce inhibitory immunoreceptor tyrosine-based activation motif signaling in atherosclerosis treatment.<h4>Materials</h4>ApoE<sup>-/-</sup> transgenic mice expressing the FcαRIR209L/FcRγ chimeric protein (FcαRIR209L/FcRγApoE<sup>-/-</sup> mice) were generated. The gene discussed is FCER1G; the disease is atherosclerosis.