Taken together, genetic CtsC deficiency or treatment with AZD7986 consistently interfered with expression of Cxcl2, Mmp9, Angpt2, and Ptpn22 which are regarded pathogenic by action on the hepatic injury (up to 24 h after APAP 42) and/or the repair/resolution (after 24 h 42) phase of ALI. Here, ANGPT2 is linked to acute respiratory distress syndrome.