This scenario highlights the need for new therapeutic options to treat peri-implantitis.<h4>Methods</h4>In this study, we proposed a novel sono-responsive antibacterial nanosystem co-loaded with metformin (Met) and bone morphogenetic protein-2 (BMP-2) to promote efficacy in treating peri-implantitis. Here, BMP2 is linked to Peri-Implantitis.