No interaction was found between <i>RPA3-UMAD1</i> rs12702634 and <i>MUC5B</i> rs35705950 (<i>P</i> = 0.70).<h4>Conclusion</h4>Our findings did not support a contribution of <i>RPA3-UMAD1</i> rs12702634 to the overall RA-ILD susceptibility in the European population. This evidence concerns the gene MUC5B and interstitial lung disease.