Among the homozygotes of KIRREL3 rs4144611 TT carriers (P = 0.003, Figure 1B), KIRREL3 rs580382 CC carriers (P = 1.2 × 10−4, Figure 1C), and EXOC6B rs61619102 CC carriers (P = 0.001, Figure 1D), higher CD34+CD133+ quartiles corresponded to a lower incidence of AD development and difference in AD-free probability with statistical significance. Here, KIRREL3 is linked to Alzheimer disease.