Notably, for these 3 SNPs, although their main SNP effects were not associated with AD risk (P > 0.40), their interactive effects with CD34+CD133 cells were significantly associated with AD after adjusting for age, sex, years of education, APOE ε4, and PCs using both logistic and Cox regression analyses (Table 5). The gene discussed is PROM1; the disease is Alzheimer disease.