Consistently, in genotype stratification analysis adjusting for age, sex, years of education, APOE ε4, and PCs, we found that CD34+CD133+ frequency was negatively associated with AD incidences among the homozygotes of KIRREL3 rs4144611 TT carriers (HR = 0.29, 95% CI: 0.15–0.57, P < 0.001), KIRREL3 rs580382 CC carriers (HR = 0.31, 95% CI: 0.17–0.57, P < 0.001), and EXOC6B rs61619102 CC carriers (HR = 0.49, 95% CI: 0.31–0.75, P < 0.001) (Table S5). Here, KIRREL3 is linked to Alzheimer disease.