KIRREL3 and Alzheimer disease: Based on these results, we hypothesized that the rescue effect of CD34+CD133+ EPCs may reduce AD risk only in vulnerable KIRREL3 rs4144611 TT carriers (Table 5 and Figure 1B and Figure S3C) and rs580382 CC carriers (Tables 5 and 6) because the low brain expression of KIRREL3 is regulated by the high brain methylation of cg11751545 in these carriers.