A mutated paired box 3 (<i>PAX3</i>​​​​​) gene manifests as type 1 Waardenburg, which is characterized by sideways displacement of the inner angles of the eyes (i.e., dystopia canthorum), widely spaced eyes, congenital sensorineural hearing impairment, and patchy pigmentation of the iris, skin, and hair. The gene discussed is PAX3; the disease is Hearing impairment.