As part of this ClinGen initiative, the Hereditary Breast, Ovarian and Pancreatic Cancer (HBOP) Variant Curation Expert Panel (VCEP) formed in 2018, with a goal of specifying criteria of the 2015 ACMG/AMP baseline guidelines for clinical classification of variants in ATM (MIM 607585), BARD1 (MIM 601593), BRIP1 (MIM 605882), CHEK2 (MIM 604373), PALB2 (MIM 610355), RAD51C (MIM 602774), and RAD51D (MIM 602954) (https://clinicalgenome.org/affiliation/50039/). The gene discussed is ATM; the disease is familial pancreatic carcinoma.